Reducing cooling load of car cabin is urgent issue to prevent global warming problems. HVAC controlled efficiently for the human body is required. But, it is difficult to evaluate the environment of car cabin by PMV or SET* which is generally used for that of architecture. Therefore, ISO14505 gives guidelines for the assessment of the thermal conditions inside a vehicle compartment. The assessment principle is based on the measurement of the equivalent temperature. Meanwhile, the numerical thermoregulation model is tried to predict the detailed human response. But the problem remains on evaluating thermal environment in non-uniform conditions. The development of the simulation technology is required. The purpose of the study is to improve the evaluation of thermal comfort under non-uniform and transient conditions. The prediction of local physiological response is tried. An experiment was held to analyze a human response in car cabin under summer condition. The result was used for the improvement of the numerical thermoregulation model JOS. And the result was predicted by CFD combined with the numerical thermoregulation model JOS.